The Methylene Tetrahydrofolate Reductase Gene Variant C677T is not Associated with Migraine in Twelve Sudanese Pedigrees with Migraine

No definitive pathophysiology exists for migraine yet, nevertheless, many theories were postulated with the most ancient one being the vascular theory which was developed by H. Wolff during the 1940s [1]. According to Lauritzen, Wolff described migraine as a vasospastic disorder that is initiated by vasoconstriction in the cranial vasculature. The vasoconstriction is then followed by dilatation of intracranial or extracranial blood vessels. Dilation of the richly innervated meningeal blood vessels activates the trigeminal sensory nerves that surround these blood vessels, initiating pain. The activated trigeminal nerves release vasoactive neuropeptides that further contribute to dilation and worsening of the pain [2].